rs114111025

This is a intron variant variant in the KDM4C gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

plasminogen activator inhibitor 1 measurement

McCartney DL et al. “Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging.” Genome Biology 22(1):194 (2021)

Allele A

OR 604.16

p 3.0e-9

N 6,149

Large GWAS

African American or Afro-Caribbean

About KDM4C

This gene is a member of the Jumonji domain 2 (JMJD2) family. The encoded protein is a trimethylation-specific demethylase, and converts specific trimethylated histone residues to the dimethylated form. This enzymatic action regulates gene expression and chromosome segregation. Chromosomal aberrations and changes in expression of this gene may be found in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

View all KDM4C variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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