KDM4C

lysine demethylase 4C

Summary

This gene is a member of the Jumonji domain 2 (JMJD2) family. The encoded protein is a trimethylation-specific demethylase, and converts specific trimethylated histone residues to the dimethylated form. This enzymatic action regulates gene expression and chromosome segregation. Chromosomal aberrations and changes in expression of this gene may be found in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Known Variants89 total

rsidPosition (GRCh37)AllelesClassClinVar
rs5741382369:6,720,948G/Cuncertain significance
rs3735029909:6,720,959A/Guncertain significance
rs108154689:6,784,726G/T
rs7490108789:6,793,056T/Cuncertain significance
rs1424194149:6,793,115C/Tuncertain significance
rs5721487979:6,805,685C/Tlikely benign
rs7454778409:6,814,685G/Tuncertain significance
rs3728782769:6,814,707A/Guncertain significance
rs47422699:6,849,317G/Aintron variant
rs7508495899:6,849,508G/Tuncertain significance
rs617503149:6,849,518A/Gbenign
rs1928321919:6,849,579A/Guncertain significance
rs18384700919:6,849,650C/Tlikely benign
rs78643519:6,849,689G/Cbenign
rs1444886379:6,877,262G/Aintron variant
rs1822554639:6,880,058C/Guncertain significance
rs1478680429:6,887,978C/Guncertain significance
rs3694851749:6,888,029C/Tuncertain significance
rs1143714709:6,888,034T/Cbenign
rs1441123229:6,899,218A/Gupstream gene variant
rs101159209:6,926,233G/Aintron variant
rs109759179:6,937,491G/Cintron variant
rs5545962379:6,953,063T/G
rs8188989:6,970,806A/C
rs13405139:6,977,633G/Aintron variant
rs13459926599:6,980,958A/Guncertain significance
rs7622118319:6,980,985C/Tuncertain significance
rs13763268579:6,981,021A/Guncertain significance
rs5607447789:6,981,070T/Auncertain significance
rs350498419:6,981,115G/Auncertain significance
rs2014159629:6,984,189C/Guncertain significance
rs24911580159:6,984,275G/Auncertain significance
rs9309827869:6,984,303C/Tuncertain significance
rs1459516889:6,984,375A/Guncertain significance
rs7753657439:6,986,368T/Cuncertain significance
rs1507615769:6,986,379A/Guncertain significance
rs12252527609:6,986,394G/Auncertain significance
rs1127821489:6,986,421C/Auncertain significance
rs3748875519:6,986,427A/Guncertain significance
rs7570844389:6,986,497C/Tuncertain significance
rs18177537629:6,986,592C/Auncertain significance
rs7802500759:6,986,632C/Guncertain significance
rs7795120519:6,986,647A/Guncertain significance
rs2020029459:6,990,419G/Alikely benign
rs7746427189:6,990,477C/Tuncertain significance
rs1423549649:6,990,494C/Guncertain significance
rs18227329749:7,011,722A/Guncertain significance
rs1383881249:7,011,796G/Auncertain significance
rs18231354209:7,013,793T/Auncertain significance
rs1480146369:7,013,824G/Auncertain significance
rs3714199699:7,013,842G/Cuncertain significance
rs350063569:7,013,874C/Tbenign
rs24917532099:7,015,881C/Guncertain significance
rs109759909:7,026,716G/C
rs107588219:7,030,268G/Tintron variant
rs14078629:7,032,776G/C
rs169251879:7,043,455C/Gintron variant
rs14151273709:7,049,096G/Auncertain significance
rs7523259369:7,049,118C/Auncertain significance
rs9259721939:7,049,139C/Tuncertain significance
rs7777832199:7,049,172G/Tuncertain significance
rs10572009:7,050,341C/T
rs108155099:7,051,245G/A
rs1141110259:7,053,666A/Cintron variant
rs47422939:7,057,536G/Tintron variant
rs3707877119:7,103,702A/Cuncertain significance
rs7649027259:7,103,706C/Tuncertain significance
rs3706230289:7,103,748G/Auncertain significance
rs7620933429:7,103,761C/Auncertain significance
rs340243399:7,103,795G/Abenign
rs7543906479:7,103,796G/Auncertain significance
rs7704994199:7,103,848G/Auncertain significance
rs1158132509:7,103,858C/Gbenign
rs7753265259:7,103,866A/Guncertain significance
rs7597823099:7,128,075G/Tuncertain significance
rs7756426829:7,128,081G/Auncertain significance
rs7226289:7,146,888G/T
rs120011589:7,155,356A/T
rs7778275569:7,165,248G/Tuncertain significance
rs7474653049:7,165,301G/Auncertain significance
rs3677390289:7,165,314A/Guncertain significance
rs108155339:7,165,946A/Gintron variant
rs7732330649:7,169,886G/Auncertain significance
rs791095589:7,171,041C/Tintron variant
rs801011079:7,174,252A/C
rs18452786769:7,174,598G/Auncertain significance
rs18452800979:7,174,611G/Tuncertain significance
rs9266924059:7,174,719A/Guncertain significance
rs18452907959:7,174,722G/Tuncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.