rs1144566

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

chronotype measurement

Jones SE et al. “Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms.” Nature Communications 10(1):343 (2019)

Allele T

OR 1.26

p 2.0e-95

N 449,734

Large GWAS

European

Hammerschlag AR et al. “Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits.” Nature Genetics 49(11):1584-1592 (2017)

Allele T

OR 0.07

p 3.0e-8

N 112,866

Large GWAS

European

circadian rhythm

Lane JM et al. “Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank.” Nature Communications 7:10889 (2016)

Allele C

OR 0.10

p 3.0e-14

N 100,420

Major Consortium StudyLarge GWAS

European

physical activity measurement

Qi G et al. “Genome-wide association studies of 27 accelerometry-derived physical activity measurements identified novel loci and genetic mechanisms.” Genetic Epidemiology 46(2):122-138 (2022)

Allele T

OR —

β 0.086

p 5.0e-10

N 88,411

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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