rs115287176
This is a protein-altering variant in the TMOD4 gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
coronary artery disease
Yamada Y et al. “Identification of 26 novel loci that confer susceptibility to early-onset coronary artery disease in a Japanese population.” Biomedical Reports 9(5):383-404 (2018)
Allele G
OR 33.33
p 1.0e-28
N 7,256
Large GWAS
East Asian
myocardial infarction
Yamada Y et al. “Identification of 13 novel susceptibility loci for early-onset myocardial infarction, hypertension, or chronic kidney disease.” International Journal of Molecular Medicine 42(5):2415-2436 (2018)
Allele G
OR 100.00
p 9.0e-25
N 6,926
Large GWAS
East Asian
Ischemic stroke
Yamada Y et al. “Identification of nine genes as novel susceptibility loci for early-onset ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage.” Biomedical Reports 9(1):8-20 (2018)
Allele G
OR 12.50
p 9.0e-9
N 6,224
Large GWAS
East Asian
About TMOD4
Predicted to enable tropomyosin binding activity. Predicted to be involved in actin filament organization; muscle contraction; and myofibril assembly. Located in striated muscle thin filament. [provided by Alliance of Genome Resources, Jul 2025]
View all TMOD4 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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