rs11548618
This variant is located in the CXCL10 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
C-X-C motif chemokine 10 measurement
Zhao JH et al. “Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets.” Nature Immunology 24(9):1540-1551 (2023)
Allele A
OR 1.94
p 6.0e-271
N 14,744
Large GWAS
multi-ancestry
Allele A
OR 1.92
p 2.0e-49
N 3,301
Large GWAS
European
Suhre K et al. “Connecting genetic risk to disease end points through the human blood plasma proteome.” Nature Communications 8:14357 (2017)
Allele A
OR 1.84
p 5.0e-21
N 997
Small GWAS
multi-ancestry
Enroth S et al. “Strong effects of genetic and lifestyle factors on biomarker variation and use of personalized cutoffs.” Nature Communications 5:4684 (2014)
Allele A
OR 1.80
p 7.0e-37
N 970
Small GWAS
Kalnapenkis A et al. “Genetic determinants of plasma protein levels in the Estonian population.” Scientific Reports 14(1):7694 (2024)
Allele A
OR 2.05
p 2.0e-17
N 489
Small GWAS
European
▶ClinVar annotation
Benign★★★☆
2 submitters2 publicationsAbout CXCL10
This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. This gene may also be a key regulator of the 'cytokine storm' immune response to SARS-CoV-2 infection. [provided by RefSeq, Sep 2020]
View all CXCL10 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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