CXCL10
C-X-C motif chemokine ligand 10
Summary
This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. This gene may also be a key regulator of the 'cytokine storm' immune response to SARS-CoV-2 infection. [provided by RefSeq, Sep 2020]
Known Variants6 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs139813823 | 4:76,943,554 | G/T | — | benign |
| rs367836661 | 4:76,943,595 | T/C | — | uncertain significance |
| rs2476657195 | 4:76,943,874 | G/A | — | uncertain significance |
| rs201830102 | 4:76,943,943 | C/T | — | uncertain significance |
| rs11548618 | 4:76,943,947 | G/A | — | benign |
| rs762956789 | 4:76,943,949 | A/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.