rs115735578
This is a upstream gene variant variant in the LMAN1L gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
squamous cell lung carcinoma
Byun J et al. “Genome-wide association study for lung cancer in 6531 African Americans reveals new susceptibility loci.” Human Molecular Genetics 34(14):1227-1237 (2025)
Allele A
OR 4.23
p 1.0e-8
N 4,781
Large GWAS
African American or Afro-Caribbean
About LMAN1L
This gene encodes a mannose-binding type 1 transmembrane protein that contains an N-terminal lectin-like carbohydrate recognition domain. The encoded protein is similar in structure to lectins found in leguminous plants. This lectin is thought to transport newly synthesized glycoproteins from the endoplasmic reticulum (ER) to the ER-Golgi intermediate compartment. [provided by RefSeq, Jan 2017]
View all LMAN1L variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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