rs11575839

This is a synonymous variant in the NCR3 gene — it does not change the protein's amino acid sequence.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

complement C4 measurement

Yang X et al. “Genome-wide association study for serum complement C3 and C4 levels in healthy Chinese subjects.” Plos Genetics 8(9):e1002916 (2012)
Allele A
OR 0.23
p 1.0e-54
N 1,999
Large GWAS
East Asian
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Research that mentions this SNP (1)

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Genetic variation in the TLR and NF‐κB pathways and cervical and vulvar cancer risk: A population‐based case–control study
AssociationN=2,493Clara Bodelon et al.(2014)· International Journal of Cancer

Population-based case-control study of 876 cervical cancer cases, 517 vulvar cancer cases, and 1,100 controls examining genetic variation in TLR and NFκB pathways. The TNF region was significantly associated with cervical cancer (gene-based P=2.0×10⁻⁴) and vulvar cancer (gene-based P=1.0×10⁻⁴) risk. The rare A allele of rs2239704 in the LTA gene 5' UTR was significantly associated with increased cervical cancer risk (OR=1.31, 95% CI: 1.15–1.50) and vulvar cancer risk (OR=1.51, 95% CI: 1.30–1.75).

Traits studied:Cervical cancerVulvar cancer
PubMedDOIMetascience Observatory

About NCR3

The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]

View all NCR3 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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