rs11579246

This is a intron variant variant in the ELAVL4 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

major depressive disorder

Howard DM et al. “Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.” Nature Neuroscience 22(3):343-352 (2019)
Allele A
OR 1.03
p 9.0e-18
N 807,553
Meta-analysisLarge GWAS
European
Meng X et al. “Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference.” Nature Genetics 56(2):222-233 (2024)
Allele A
OR 0.04
p 4.0e-16
N 1,820,689
Large GWAS
multi-ancestry
Als TD et al. “Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses.” Nature Medicine 29(7):1832-1844 (2023)
Allele A
OR 0.03
p 6.0e-10
N 1,349,887
Large GWAS
European
Yao X et al. “Integrative analysis of genome-wide association studies identifies novel loci associated with neuropsychiatric disorders.” Translational Psychiatry 11(1):69 (2021)
Allele A
OR 0.05
p 1.0e-10
N 500,199
Large GWAS
European

About ELAVL4

Enables mRNA 3'-UTR AU-rich region binding activity; poly(A) binding activity; and pre-mRNA intronic pyrimidine-rich binding activity. Involved in 3'-UTR-mediated mRNA stabilization; RNA processing; and positive regulation of 3'-UTR-mediated mRNA stabilization. Predicted to be located in axon; cytoplasm; and dendrite. Predicted to be part of ribonucleoprotein complex. Predicted to be active in glutamatergic synapse. [provided by Alliance of Genome Resources, Jul 2025]

View all ELAVL4 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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