rs115882880

This is a regulatory region variant variant in the GRIN3B gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Alzheimer disease, APOE carrier status

Rajabli F et al. “Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease.” Genome Biology 26(1):210 (2025)

Allele A

OR 1.23

p 1.0e-9

N 56,241

Meta-analysisLarge GWAS

multi-ancestry

Alzheimer disease, dementia, family history of Alzheimer’s disease

Sherva R et al. “Genome-wide association studies of Alzheimer's disease and related disorders stratified by sex, onset age, and Apolipoprotein E genotype reveal novel risk loci in African Americans.” Alzheimer's Research & Therapy 17(1):171 (2025)

Allele A

OR 1.35

p 2.0e-9

N 56,917

Large GWAS

African American or Afro-Caribbean

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Research that mentions this SNP (1)

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Variants in the ATP-Binding Cassette Transporter (ABCA7), Apolipoprotein E ϵ4, and the Risk of Late-Onset Alzheimer Disease in African Americans

AssociationN=5,896Reitz C. et al.(2013)· JAMA

This GWAS meta-analysis in 5,896 African Americans (1,968 cases, 3,928 controls) identified rs115550680 in ABCA7 as significantly associated with late-onset Alzheimer disease (AD) (OR=1.79, 95% CI 1.47-2.12, P=2.2×10⁻⁹), with effect size comparable to APOE ε4 (rs429358, OR=2.31, P=5.5×10⁻⁴⁷). Additional AD-associated loci identified in African Americans included variants in CR1, BIN1, EPHA1, and CD33, some differing from European ancestry findings.

Traits studied:Late-onset Alzheimer disease

PubMed DOI Metascience Observatory

About GRIN3B

The protein encoded by this gene is a subunit of an N-methyl-D-aspartate (NMDA) receptor. The encoded protein is found primarily in motor neurons, where it forms a heterotetramer with GRIN1 to create an excitatory glycine receptor. Variations in this gene have been proposed to be linked to schizophrenia. [provided by RefSeq, Nov 2015]