rs11602961

This variant is located in the AGBL2 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

systolic blood pressure

Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)

Allele T

OR 0.02

p 4.0e-11

N 1,212,859

Large GWAS

European

peripheral arterial disease, coronary artery disease

Bellomo TR et al. “Multi-Trait Genome-Wide Association Study of Atherosclerosis Detects Novel Pleiotropic Loci.” Frontiers in Genetics 12:787545 (2021)

Allele C

OR —

p 9.0e-9

N 722,253

Large GWAS

European

About AGBL2

Predicted to enable metallocarboxypeptidase activity and tubulin binding activity. Predicted to be involved in protein side chain deglutamylation. Located in centriole and ciliary basal body. [provided by Alliance of Genome Resources, Jul 2025]

View all AGBL2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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