rs11651052

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GWAS Catalog Trait Associations (6)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

type 2 diabetes mellitus

Suzuki K et al. “Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.” Nature 627(8003):347-357 (2024)
Allele A
OR —
p 2.0e-123
N 2,535,601
Large GWAS
multi-ancestry
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele A
OR 0.09
p 5.0e-44
N 667,504
Large GWAS
multi-ancestry
Suzuki K et al. “Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population.” Nature Genetics 51(3):379-386 (2019)
Allele A
OR 1.12
p 2.0e-34
N 191,764
Large GWAS
East Asian
Morris AP et al. “Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes” Nature Genetics (2012)
Allele A
OR 1.13
p 3.0e-9
N 69,033
Large GWAS
multi-ancestry

prostate carcinoma

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele G
OR 0.23
p 5.0e-79
N 301,559
Large GWAS
multi-ancestry
Gudmundsson J et al. “Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA.” Nature Communications 9(1):4568 (2018)
Allele G
OR 1.22
p 2.0e-40
N 295,892
Large GWAS
European
Teerlink CC et al. “Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21” Human Genetics (2016)
Allele G
OR 1.37
p 3.0e-10
N 3,893
Large GWAS
European

prostate cancer

Harris BHL et al. “New role of fat-free mass in cancer risk linked with genetic predisposition.” Scientific Reports 14(1):7270 (2024)
Allele G
OR 0.21
p 4.0e-34
N 151,994
Large GWAS
European

Drugs used in diabetes use measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele G
OR 0.12
p 1.0e-28
N 178,726
Large GWAS
East Asian

prostate specific antigen amount

Gudmundsson J et al. “Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA.” Nature Communications 9(1):4568 (2018)
Allele A
OR —
β 0.058
p 2.0e-24
N 33,572
Large GWAS
European
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Research that mentions this SNP (1)

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Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21
AssociationN=3,893Teerlink CC et al.(2016)· Human Genetics

This genome-wide association study of 2511 familial prostate cancer cases and 1382 controls identified significant associations in six regions previously linked to prostate cancer risk. Most notably, rs138042437 at 8q24.21 achieved an exceptionally large effect size (OR=13.3, p=1.7e-8) and demonstrated strong co-segregation with disease in 116 affected relatives (p=8.5e-11). The study identified a rare segregating haplotype at 8q24.21 containing three SNPs (rs183373024, rs188140481, rs138042437) that characterized a prostate cancer predisposition locus.

Traits studied:Aggressive prostate cancerFamilial prostate cancerProstate cancer
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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