rs11668344
This variant is located in the TMEM150B gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
age at menopause
Ruth KS et al. “Genetic insights into biological mechanisms governing human ovarian ageing.” Nature 596(7872):393-397 (2021)
Allele A
OR 0.43
p —
N 201,323
Large GWAS
multi-ancestry
Day FR et al. “Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.” Nature Genetics 47(11):1294-1303 (2015)
Allele A
OR 0.41
p 6.0e-85
N 69,626
Large GWAS
European
Stolk L et al. “Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.” Nature Genetics 44(3):260-8 (2012)
Allele A
OR 0.42
p 1.0e-59
N 38,968
Large GWAS
European
Perry JR et al. “A genome-wide association study of early menopause and the combined impact of identified variants.” Human Molecular Genetics 22(7):1465-72 (2013)
Allele A
OR 0.30
p 5.0e-26
N 17,091
Large GWAS
European
ovulation
D'Urso S et al. “Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk.” Bmc Medicine 20(1):419 (2022)
Allele G
OR 0.39
p 3.0e-24
N 118,227
Large GWAS
European
About TMEM150B
This gene encodes a protein that belongs to the DRAM (damage-regulated autophagy modulator) family of membrane-spanning proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
View all TMEM150B variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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