rs11674184
This is a upstream gene variant variant in the GREB1 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
endometriosis
Rahmioglu N et al. “The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions.” Nature Genetics 55(3):423-436 (2023)
Allele T
OR 1.16
p 6.0e-9
N 383,935
Large GWAS
European
Shigesi N et al. “The phenotypic and genetic association between endometriosis and immunological diseases.” Human Reproduction (oxford, England) 40(6):1195-1209 (2025)
Allele T
OR 0.03
p 2.0e-25
N 217,530
Large GWAS
European
Sapkota Y et al. “Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism.” Nature Communications 8:15539 (2017)
Allele T
OR 1.13
p 3.0e-17
N 208,903
Meta-analysisLarge GWAS
multi-ancestry
About GREB1
This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
View all GREB1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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