rs11681373

This is a intron variant variant in the ZNF804A gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

alcohol use disorder measurement

Kember RL et al. “Genetic Underpinnings of the Transition From Alcohol Consumption to Alcohol Use Disorder: Shared and Unique Genetic Architectures in a Cross-Ancestry Sample.” The American Journal of Psychiatry 180(8):584-593 (2023)
Allele A
OR 5.49
p 4.0e-8
N 409,630
Large GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Effect of DISC1 SNPs on brain structure in healthy controls and patients with a history of psychosis
ReviewN=113Anna K. Kähler et al.(2012)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

This systematic review and validation study examined psychosis-associated SNPs and their effects on brain volumetry in 113 subjects (schizophrenia, bipolar disorder, at-risk mental state, and healthy controls). Of 25 studies identified in the systematic review implicating 7 SNPs in 5 genes, the authors tested these variants using voxel-based morphometry. They found FWER-corrected associations for CACNA1C rs769087-A with larger bilateral hippocampus and thalamus white matter (p = 0.026 and p = 0.036) and with larger superior frontal gyrus volume. Higher replication concordance was found for CACNA1C, ZNF804A, and BDNF variants, supporting their involvement in psychosis and brain structure.

Traits studied:Bipolar disorderBrain volumetryGrey matter volumePsychotic disordersSchizophreniaWhite matter volume
PubMedDOIMetascience Observatory

About ZNF804A

The protein encoded by this gene is a zinc finger binding protein. Polymorphisms in this gene, especially rs1344706, are thought to confer increased susceptibility to schizophrenia, bipolar disorder, and heroin addiciton. [provided by RefSeq, Nov 2015]

View all ZNF804A variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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