rs1169297

This is a intron variant variant in the HNF1A gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

depressive symptom measurement, low density lipoprotein cholesterol measurement

Bentley AR et al. “Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids.” Translational Psychiatry 15(1):207 (2025)

Allele A

OR —

β 0.755

p 4.0e-11

N 89,939

Large GWAS

European

cholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele G

OR 0.02

p 3.0e-8

N 115,082

Large GWAS

European

About HNF1A

The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

rs1169297

GWAS Catalog Trait Associations (2)

depressive symptom measurement, low density lipoprotein cholesterol measurement

cholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement

About HNF1A

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