rs11732231
This is a regulatory region variant variant in the ARHGAP24 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
PR interval
Butler AM et al. “Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts.” Circulation. Cardiovascular Genetics 5(6):639-46 (2012)
Allele C
OR 2.28
p 3.0e-9
N 13,415
Large GWAS
African American or Afro-Caribbean
About ARHGAP24
This gene encodes a Rho-GTPase activating protein, which is specific for the small GTPase family member Rac. Binding of the encoded protein by filamin A targets it to sites of membrane protrusion, where it antognizes Rac. This results in suppression of lamellae formation and promotion of retraction to regulate cell polarity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
View all ARHGAP24 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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