rs11740553

This is a regulatory region variant variant in the TPPP gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

C-C motif chemokine 18 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.05
p 1.0e-15
N 47,745
Large GWAS
European

About TPPP

Enables several functions, including magnesium ion binding activity; microtubule nucleator activity; and protein homodimerization activity. Involved in several processes, including microtubule cytoskeleton organization; negative regulation of tubulin deacetylation; and positive regulation of protein polymerization. Located in several cellular components, including cytoskeleton; mitochondrion; and perinuclear region of cytoplasm. Is active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2025]

View all TPPP variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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