TPPP
tubulin polymerization promoting protein
Summary
Enables several functions, including magnesium ion binding activity; microtubule nucleator activity; and protein homodimerization activity. Involved in several processes, including microtubule cytoskeleton organization; negative regulation of tubulin deacetylation; and positive regulation of protein polymerization. Located in several cellular components, including cytoskeleton; mitochondrion; and perinuclear region of cytoplasm. Is active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2025]
Known Variants42 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs9918259 | 5:663,092 | C/T | regulatory region variant | — |
| rs1345590978 | 5:665,228 | C/T | — | uncertain significance |
| rs529523544 | 5:665,244 | G/A | — | likely benign |
| rs141487731 | 5:665,256 | G/A | — | benign |
| rs766450034 | 5:665,274 | A/G | — | likely benign |
| rs2478582358 | 5:665,275 | T/C | — | uncertain significance |
| rs748630491 | 5:665,285 | C/T | — | uncertain significance |
| rs2478582880 | 5:665,314 | C/A | — | uncertain significance |
| rs778130148 | 5:665,358 | C/T | — | likely benign |
| rs140456348 | 5:665,376 | C/T | — | benign |
| rs757531846 | 5:665,377 | G/A | — | uncertain significance |
| rs1379712492 | 5:665,411 | T/C | — | uncertain significance |
| rs146377171 | 5:666,106 | C/T | — | likely benign |
| rs371896286 | 5:666,137 | C/T | — | uncertain significance |
| rs775980060 | 5:666,150 | C/T | — | uncertain significance |
| rs150708894 | 5:666,155 | C/T | — | uncertain significance |
| rs569786637 | 5:666,180 | C/T | — | uncertain significance |
| rs749246726 | 5:666,194 | G/C | — | uncertain significance |
| rs1343684883 | 5:668,161 | G/C | — | likely benign |
| rs75783973 | 5:668,309 | G/A | missense variant | — |
| rs79129291 | 5:668,322 | C/G | — | likely benign |
| rs112278350 | 5:668,430 | A/G | — | likely benign |
| rs11740553 | 5:672,593 | C/T | regulatory region variant | — |
| rs1709544 | 5:674,921 | C/A | — | — |
| rs780424812 | 5:677,858 | C/A | — | likely benign |
| rs374117987 | 5:677,881 | C/T | — | uncertain significance |
| rs7737292 | 5:678,005 | G/A | — | benign |
| rs2478723542 | 5:678,012 | A/C | — | uncertain significance |
| rs61731452 | 5:678,060 | C/G | — | benign |
| rs151029018 | 5:678,061 | C/T | — | uncertain significance |
| rs138862056 | 5:678,119 | C/T | — | likely benign |
| rs386057 | 5:685,748 | G/C | — | — |
| rs2455357 | 5:688,900 | A/T | — | — |
| rs62330329 | 5:692,887 | T/A | — | — |
| rs4990988 | 5:693,030 | A/T | — | — |
| rs111606523 | 5:693,387 | G/C | — | — |
| rs399277 | 5:694,205 | A/T | — | — |
| rs466059 | 5:696,436 | C/T | — | — |
| rs56139727 | 5:697,380 | G/C | — | — |
| rs413988 | 5:698,650 | C/G | — | — |
| rs440225 | 5:699,036 | G/T | — | — |
| rs4957107 | 5:699,647 | G/A | intergenic variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.