rs11755845
This is a intergenic variant variant in the POLR1C gene.
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
hypothyroidism
White SL et al. “Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.” Nature Genetics 58(2):307-316 (2026)
Allele T
OR 0.06
p 4.0e-39
N 1,786,062
Large GWAS
European
level of thyrotropin subunit beta in blood
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.06
p 2.0e-18
N 47,745
Large GWAS
European
hormone measurement, Thyroid stimulating hormone level
Porcu E et al. “A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.” Plos Genetics 9(2):e1003266 (2013)
Allele T
OR 0.07
p 2.0e-10
N 26,420
Meta-analysisLarge GWAS
European
Thyroid stimulating hormone level
Nolan J et al. “Genome-wide analysis of thyroid function in Australian adolescents highlights SERPINA7 and NCOA3.” European Journal of Endocrinology 185(5):743-753 (2021)
Allele T
OR —
β 0.052
p 8.0e-9
N 2,832
Large GWAS
European
About POLR1C
The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Mutations in this gene have been associated with Treacher Collins syndrome (TCS) and hypomyelinating leukodystrophy 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
View all POLR1C variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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