rs11757201

This is a intergenic variant variant.

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Oral ulcer

Dudding T et al. “Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci.” Nature Communications 10(1):1052 (2019)

Allele C

OR 1.06

p 2.0e-27

N 461,106

Large GWAS

European, NR

cytotoxic and regulatory T-cell molecule level

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele C

OR 0.05

p 9.0e-14

N 47,745

Large GWAS

European

autoimmune disease

Márquez A et al. “Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations.” Genome Medicine 10(1):97 (2018)

Allele C

OR —

p 1.0e-11

N 59,468

Meta-analysisLarge GWAS

European

rheumatoid arthritis

Márquez A et al. “Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations.” Genome Medicine 10(1):97 (2018)

Allele C

OR 1.14

p 3.0e-11

N 37,831

Meta-analysisLarge GWAS

European

tonsillectomy risk measurement

Tian C et al. “Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections.” Nature Communications 8(1):599 (2017)

Allele C

OR 1.06

p 3.0e-8

N 173,421

Large GWAS

European

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Research that mentions this SNP (1)

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Reduction of CD83 Expression on B Cells and the Genetic Basis for Rheumatoid Arthritis: Comment on the Article by Thalayasingam et al

FunctionalN=16Yumi Tsuchida et al.(2018)· Arthritis & Rheumatology

This functional study integrates epigenomic datasets (ATAC-seq, Hi-C, ChIP-seq, RNA-seq) from fibroblast-like synoviocytes (FLS) to map the functional relevance of 101 fine-mapped rheumatoid arthritis GWAS associations. FLS regulatory elements account for 24% of RA heritability, and the study assigns putative target genes to RA risk loci, identifying TNFAIP3, IFNAR1, CDK6, RBPJ and others as disease-relevant genes. TNF stimulation reveals dynamic chromatin interactions and differential gene expression at RA-associated regulatory regions.

Traits studied:Rheumatoid arthritis

PubMed DOI Metascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

rs11757201

GWAS Catalog Trait Associations (5)

Oral ulcer

cytotoxic and regulatory T-cell molecule level

autoimmune disease

rheumatoid arthritis

tonsillectomy risk measurement

Research that mentions this SNP (1)

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