rs11795343

This is a intron variant variant in the DDX58 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

psoriasis

Zhang M et al. “Multi-ancestry genome-wide meta-analysis with 472,819 individuals identifies 32 novel risk loci for psoriasis.” Journal of Translational Medicine 23(1):133 (2025)
Allele T
OR 0.09
p 3.0e-16
N 472,819
Meta-analysisLarge GWAS
multi-ancestry
Tsoi LC et al. “Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.” Nature Genetics 44(12):1341-8 (2012)
Allele T
OR 1.11
p 8.0e-11
N 33,394
Large GWAS
European
Baurecht H et al. “Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.” American Journal of Human Genetics 96(1):104-20 (2015)
Allele T
OR 1.19
p 6.0e-9
N 12,244
Large GWAS
European

psoriasis, type 2 diabetes mellitus

Patrick MT et al. “Causal Relationship and Shared Genetic Loci between Psoriasis and Type 2 Diabetes through Trans-Disease Meta-Analysis.” The Journal of Investigative Dermatology 141(6):1493-1502 (2021)
Allele T
OR 1.07
p 1.0e-10
N 925,490
Meta-analysisLarge GWAS
European

high density lipoprotein cholesterol measurement

Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)
Allele C
OR 0.01
p 4.0e-8
N 1,320,016
Large GWAS
European
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Research that mentions this SNP (1)

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Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes
AssociationN=714Inna G. Ovsyannikova et al.(2010)· Human Genetics

A candidate gene association study of 714 healthy children examined associations between 148 SNPs in innate immunity genes (TLR, vitamin A and D receptors, RIG-I pathway, TRIM factors) and rubella vaccine-induced cytokine responses. Twenty-two significant associations (P = 0.002–0.048) were found, including rs3740996 (His43Tyr) and rs10838525 (Gln136Arg) in TRIM5 with TNFα and IL-2/GM-CSF responses, and rs5743305 in TLR3 with GM-CSF secretion.

Traits studied:Rubella vaccine-induced cytokine responseRubella virus-specific GM-CSF secretionRubella virus-specific IFNγ secretionRubella virus-specific IL-10 secretionRubella virus-specific IL-12p40 secretionRubella virus-specific IL-2 secretionRubella virus-specific IL-4 secretionRubella virus-specific IL-5 secretionRubella virus-specific IL-6 secretionRubella virus-specific TNFα secretion
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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