rs117962550

This is a intron variant variant in the ALPG gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

nephrotic syndrome

Chan H et al. “A genomic association study revealing subphenotypes of childhood steroid-sensitive nephrotic syndrome in a larger genomic sequencing cohort.” Genes & Diseases 11(4):101126 (2024)

Allele A

OR 4.13

p 7.0e-10

N 2,016

Large GWAS

East Asian

About ALPG

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme, localized to testis, thymus and certain germ cell tumors, that is closely related to both the placental and intestinal forms of alkaline phosphatase. [provided by RefSeq, Jul 2008]

View all ALPG variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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