rs117985931

This is a intron variant variant in the PLXNA4 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

concussion

Kim SK et al. “A Genome-wide Association Study for Concussion Risk.” Medicine and Science in Sports and Exercise 53(4):704-711 (2021)

Allele G

OR 3.59

p 4.0e-9

N 295,536

Large GWAS

European

About PLXNA4

Predicted to enable semaphorin receptor activity. Predicted to be involved in nervous system development; regulation of cell migration; and semaphorin-plexin signaling pathway. Predicted to act upstream of or within nervous system development; regulation of axon extension involved in axon guidance; and regulation of negative chemotaxis. Predicted to be located in membrane. Predicted to be part of semaphorin receptor complex. Predicted to be active in cerebellar climbing fiber to Purkinje cell synapse and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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