rs11874

This variant is located in the GOSR2 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Agents acting on the renin-angiotensin system use measurement

Wu Y et al. “Genome-wide association study of medication-use and associated disease in the UK Biobank.” Nature Communications 10(1):1891 (2019)

Allele A

OR 0.06

p 2.0e-13

N 237,530

Major Consortium StudyLarge GWAS

European

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele A

OR 0.06

p 2.0e-13

N 416,256

Large GWAS

multi-ancestry

QT interval

Hoffmann TJ et al. “A large genome-wide association study of QT interval length utilizing electronic health records.” Genetics 222(4) (2022)

Allele G

OR 0.87

p 2.0e-10

N 117,532

Large GWAS

multi-ancestry

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ClinVar annotation

Likely Benign★★★☆

2 submitters1 publication

Progressive myoclonic epilepsy; not provided

View on ClinVar →

About GOSR2

This gene encodes a trafficking membrane protein which transports proteins among the medial- and trans-Golgi compartments. Due to its chromosomal location and trafficking function, this gene may be involved in familial essential hypertension. [provided by RefSeq, Mar 2016]