rs11876749

This variant is located in the DLGAP1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

eyelid functionality

Jacobs LC et al. “Intrinsic and Extrinsic Risk Factors for Sagging Eyelids” Jama Dermatology (2014)
Allele C
OR 0.14
p 2.0e-8
N 6,631
Large GWAS
European
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Research that mentions this SNP (1)

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Intrinsic and Extrinsic Risk Factors for Sagging Eyelids
AssociationN=6,631Jacobs LC et al.(2014)· JAMA Dermatology

Genome-wide association study of sagging eyelids (dermatochalasis) in 5,578 Rotterdam Study participants and 1,053 TwinsUK twins identified a genome-wide significant protective effect for the C allele of rs11876749 (P=1.7×10⁻⁸) in a recessive model. Risk factors included age, male sex, lighter skin color, and higher BMI. Heritability of sagging eyelids was estimated at 61% in the twin cohort.

Traits studied:DermatochalasisSagging eyelidsSkin agingSkin wrinkling
PubMedDOIMetascience Observatory

About DLGAP1

Predicted to enable molecular adaptor activity. Predicted to be a structural constituent of postsynaptic density. Predicted to be involved in several processes, including aggresome assembly; protein localization to synapse; and regulation of proteasomal protein catabolic process. Predicted to be located in plasma membrane. Predicted to be active in glutamatergic synapse and postsynaptic density, intracellular component. [provided by Alliance of Genome Resources, Jul 2025]

View all DLGAP1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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