rs11887523
This is a protein-altering variant in the MFSD2B gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
HbA1c measurement
Downie CG et al. “Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study.” Diabetologia 65(3):477-489 (2022)
Allele A
OR 0.29
p 6.0e-15
N 23,357
Large GWAS
European, African American or Afro-Caribbean, Hispanic or Latin American, Asian unspecified
Willems SM et al. “Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization.” Wellcome Open Research 8:483 (2023)
Allele A
OR 0.07
p 1.0e-12
N 144,060
Large GWAS
multi-ancestry
Red cell distribution width
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.09
p 2.0e-20
N 110,558
Major Consortium StudyLarge GWAS
African American or Afro-Caribbean
About MFSD2B
Enables sphingolipid transporter activity. Involved in lipid transport. Is active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all MFSD2B variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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