rs11927381

This is a intron variant variant in the IGF2BP2 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

insulin measurement

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele T

OR 0.11

p 2.0e-17

N 619,297

Major Consortium StudyLarge GWAS

multi-ancestry

low density lipoprotein cholesterol measurement

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele T

OR 0.02

p 2.0e-14

N 404,741

Major Consortium StudyLarge GWAS

European

type 2 diabetes mellitus

Cook JP et al. “Multi-ethnic genome-wide association study identifies novel locus for type 2 diabetes susceptibility.” European Journal of Human Genetics : Ejhg 24(8):1175-80 (2016)

Allele C

OR 1.14

p 3.0e-14

N 71,604

Large GWAS

multi-ancestry

About IGF2BP2

This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016]