rs12019136
This is a intron variant variant in the FUT6 gene.
▶GWAS Catalog Trait Associations (9)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (9)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
N-glycan measurement
Sharapov S et al. “A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins.” Nature Communications 16(1):5525 (2025)
Allele A
OR 1.11
p 4.0e-167
N 10,172
Large GWAS
European
vitamin B12 measurement
Jacobs BM et al. “Genetic architecture of routinely acquired blood tests in a British South Asian cohort.” Nature Communications 15(1):8929 (2024)
Allele A
OR 0.18
p 2.0e-54
N 38,000
Large GWAS
South Asian
alpha-(1;3)-fucosyltransferase 5 measurement
Thareja G et al. “Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.” Human Molecular Genetics 32(6):907-916 (2023)
Allele A
OR 0.76
p 4.0e-50
N 2,935
Large GWAS
Greater Middle Eastern (Middle Eastern, North African or Persian)
lactoperoxidase measurement
Thareja G et al. “Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.” Human Molecular Genetics 32(6):907-916 (2023)
Allele A
OR 0.72
p 1.0e-44
N 2,935
Large GWAS
Greater Middle Eastern (Middle Eastern, North African or Persian)
interleukin-18 receptor 1 measurement
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.06
p 5.0e-26
N 47,745
Large GWAS
European
cathepsin L2 measurement
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.11
p 5.0e-20
N 47,745
Large GWAS
European
E-selectin amount
Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)
Allele A
OR 0.25
p 1.0e-14
N 10,708
Large GWAS
European
serum IgG glycosylation measurement
Shen X et al. “Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation.” Nature Communications 8(1):447 (2017)
Allele A
OR —
p 2.0e-13
N 1,960
Large GWAS
European
transferrin glycosylation measurement
Landini A et al. “Genetic regulation of post-translational modification of two distinct proteins.” Nature Communications 13(1):1586 (2022)
Allele A
OR 0.84
p 2.0e-22
N 1,890
Large GWAS
European
About FUT6
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
View all FUT6 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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