rs12117
This variant is located in the HPX gene.
▶GWAS Catalog Trait Associations (16)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (16)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
level of syntaxin-17 in blood serum
Surapaneni A et al. “Identification of 969 protein quantitative trait loci in an African American population with kidney disease attributed to hypertension.” Kidney International 102(5):1167-1177 (2022)
Allele A
OR 1.90
p 1.0e-54
N 466
Small GWAS
African American or Afro-Caribbean
apolipoprotein L1 measurement
Surapaneni A et al. “Identification of 969 protein quantitative trait loci in an African American population with kidney disease attributed to hypertension.” Kidney International 102(5):1167-1177 (2022)
Allele A
OR 1.78
p 2.0e-50
N 466
Small GWAS
African American or Afro-Caribbean
tumor necrosis factor ligand superfamily member 18 amount
Surapaneni A et al. “Identification of 969 protein quantitative trait loci in an African American population with kidney disease attributed to hypertension.” Kidney International 102(5):1167-1177 (2022)
Allele A
OR 1.82
p 4.0e-48
N 466
Small GWAS
African American or Afro-Caribbean
level of core-binding factor subunit beta in blood serum
Surapaneni A et al. “Identification of 969 protein quantitative trait loci in an African American population with kidney disease attributed to hypertension.” Kidney International 102(5):1167-1177 (2022)
Allele A
OR 1.75
p 8.0e-48
N 466
Small GWAS
African American or Afro-Caribbean
level of exportin-5 in blood serum
Surapaneni A et al. “Identification of 969 protein quantitative trait loci in an African American population with kidney disease attributed to hypertension.” Kidney International 102(5):1167-1177 (2022)
Allele A
OR 1.74
p 2.0e-47
N 466
Small GWAS
African American or Afro-Caribbean
level of NTF2-related export protein 2 in blood serum
Surapaneni A et al. “Identification of 969 protein quantitative trait loci in an African American population with kidney disease attributed to hypertension.” Kidney International 102(5):1167-1177 (2022)
Allele A
OR 1.70
p 4.0e-44
N 466
Small GWAS
African American or Afro-Caribbean
tumor necrosis factor amount
Surapaneni A et al. “Identification of 969 protein quantitative trait loci in an African American population with kidney disease attributed to hypertension.” Kidney International 102(5):1167-1177 (2022)
Allele A
OR 1.63
p 1.0e-39
N 466
Small GWAS
African American or Afro-Caribbean
level of homeobox protein SIX6 in blood serum
Surapaneni A et al. “Identification of 969 protein quantitative trait loci in an African American population with kidney disease attributed to hypertension.” Kidney International 102(5):1167-1177 (2022)
Allele A
OR 1.56
p 1.0e-35
N 466
Small GWAS
African American or Afro-Caribbean
level of F-BAR and double SH3 domains protein 1 in blood serum
Surapaneni A et al. “Identification of 969 protein quantitative trait loci in an African American population with kidney disease attributed to hypertension.” Kidney International 102(5):1167-1177 (2022)
Allele A
OR 1.51
p 9.0e-33
N 466
Small GWAS
African American or Afro-Caribbean
level of probable serine carboxypeptidase CPVL in blood serum
Surapaneni A et al. “Identification of 969 protein quantitative trait loci in an African American population with kidney disease attributed to hypertension.” Kidney International 102(5):1167-1177 (2022)
Allele A
OR 1.37
p 9.0e-26
N 466
Small GWAS
African American or Afro-Caribbean
▶ClinVar annotation
Benign★★★☆
2 submitters2 publicationsAbout HPX
This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress. [provided by RefSeq, Apr 2009]
View all HPX variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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