rs12188300

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GWAS Catalog Trait Associations (9)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

psoriasis

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.33
p 5.0e-75
N 629,965
Major Consortium StudyLarge GWAS
multi-ancestry
Tsoi LC et al. “Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.” Nature Genetics 44(12):1341-8 (2012)
Allele A
OR 1.58
p 3.0e-53
N 33,394
Large GWAS
European

psoriasis vulgaris

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.34
p 4.0e-73
N 631,875
Major Consortium StudyLarge GWAS
multi-ancestry
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele A
OR 0.40
p 3.0e-23
N 655,669
Large GWAS
multi-ancestry

erythematosquamous dermatosis

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.21
p 2.0e-57
N 425,227
Major Consortium StudyLarge GWAS
European

seborrheic dermatitis

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.22
p 3.0e-57
N 425,845
Major Consortium StudyLarge GWAS
European

psoriasis, type 2 diabetes mellitus

Patrick MT et al. “Causal Relationship and Shared Genetic Loci between Psoriasis and Type 2 Diabetes through Trans-Disease Meta-Analysis.” The Journal of Investigative Dermatology 141(6):1493-1502 (2021)
Allele T
OR 1.31
p 2.0e-56
N 925,490
Meta-analysisLarge GWAS
European

psoriatic arthritis

Hüffmeier U et al. “Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis.” Nature Genetics 42(11):996-9 (2010)
Allele T
OR 1.70
p 7.0e-17
N 1,460
Large GWAS
European

level of defensin beta 4A in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.07
p 7.0e-14
N 47,745
Large GWAS
European

drug use measurement, skin disease

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.16
p 1.0e-18
N 404,034
Major Consortium StudyLarge GWAS
multi-ancestry

skin disease

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.15
p 1.0e-27
N 404,034
Major Consortium StudyLarge GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Meta-analysis of IL12B polymorphisms (rs3212227, rs6887695) with psoriasis and psoriatic arthritis
Meta-analysisN=13,050Kun-Ju Zhu et al.(2013)· Rheumatology International

Meta-analysis of 11 studies examining IL12B polymorphisms rs3212227 and rs6887695 in psoriasis and psoriatic arthritis. For rs3212227, pooled odds ratios for the minor allele were 0.688 (95% CI 0.650-0.729) for psoriasis and 0.707 (95% CI 0.628-0.797) for PsA; for rs6887695, pooled ORs were 0.704 (95% CI 0.670-0.739) for psoriasis and 0.677 (95% CI 0.599-0.767) for PsA, demonstrating significant protective associations with both variants.

Traits studied:PsoriasisPsoriasis vulgarisPsoriatic arthritis
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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