rs12275055

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

prostate carcinoma

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele G
OR 0.28
p 8.0e-44
N 301,559
Large GWAS
multi-ancestry
Rashkin SR et al. “Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts.” Nature Communications 11(1):4423 (2020)
Allele G
OR 1.26
p 1.0e-36
N 421,142
Large GWAS
European

cancer

Rashkin SR et al. “Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts.” Nature Communications 11(1):4423 (2020)
Allele G
OR 1.25
p 9.0e-33
N 475,312
Large GWAS
European
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Research that mentions this SNP (1)

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Comprehensive resequence analysis of a 123‐kb region of chromosome 11q13 associated with prostate cancer
AssociationN=84Charles C. Chung et al.(2012)· The Prostate

Comprehensive resequencing of a 122.9 kb region on chromosome 11q13.3 identified 644 polymorphic loci, including 166 novel variants not present in public databases. The study focused on fine-mapping prostate cancer susceptibility loci including rs10896438, rs12793759, rs10896449, and rs11228565, cataloguing 22-25 highly correlated surrogates (r² ≥ 0.8) for each locus and identifying functional regulatory elements. Indel polymorphisms comprised 13.4% of identified variants, with 58.5% novel to this study.

Traits studied:Prostate cancer
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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