rs12325192
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
uterine prolapse
Pujol Gualdo N et al. “Atlas of genetic and phenotypic associations across 42 female reproductive health diagnoses.” Nature Medicine 31(5):1626-1634 (2025)
Allele C
OR 1.17
p 2.0e-23
N 234,621
Large GWAS
European
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele C
OR 0.15
p 1.0e-14
N 317,583
Large GWAS
multi-ancestry
pelvic organ prolapse
Pujol-Gualdo N et al. “Advancing our understanding of genetic risk factors and potential personalized strategies for pelvic organ prolapse.” Nature Communications 13(1):3584 (2022)
Allele T
OR 0.89
p 1.0e-21
N 574,377
Large GWAS
European
Olafsdottir T et al. “Genome-wide association identifies seven loci for pelvic organ prolapse in Iceland and the UK Biobank.” Communications Biology 3(1):129 (2020)
Allele T
OR 1.12
p 3.0e-12
N 355,744
Major Consortium StudyLarge GWAS
European
Uterine leiomyoma
Pujol Gualdo N et al. “Atlas of genetic and phenotypic associations across 42 female reproductive health diagnoses.” Nature Medicine 31(5):1626-1634 (2025)
Allele C
OR 1.07
p 4.0e-12
N 295,291
Large GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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