rs12356750

This variant is located in the SFMBT2 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

smoking initiation

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)

Allele A

OR 0.01

p 5.0e-11

N 2,669,029

Large GWAS

European

About SFMBT2

Enables histone binding activity. Involved in negative regulation of gene expression. Located in aggresome; cytosol; and nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]

View all SFMBT2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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