rs12443170

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

cigarettes per day measurement

Koskeridis F et al. “Pleiotropic genetic architecture and novel loci for C-reactive protein levels.” Nature Communications 13(1):6939 (2022)
Allele A
OR 0.05
p 3.0e-42
N 337,334
Large GWAS
European
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Research that mentions this SNP (1)

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Nicotinic acetylcholine receptor genes on chromosome 15q25.1 are associated with nicotine and opioid dependence severity
AssociationN=505Erlich PM et al.(2010)· Human Genetics

This genetic association study examined 505 opioid-dependent patients and found that nicotinic acetylcholine receptor (nAChR) gene variants on chromosome 15q25.1 are associated with both nicotine dependence severity and opioid dependence severity. The CHRNA5 coding variant rs16969968[A] was significantly associated with 1.4-unit higher opioid dependence severity (p < 0.00017), while CHRNA3 variant rs660652[G] was associated with 1.7-fold higher smoking odds and 1.1-unit higher nicotine dependence (p < 0.0007). These findings extend the known role of the 15q25.1 locus from nicotine to prescription opioid dependence phenotypes.

Traits studied:Attempts to quit smokingNicotine dependence severityOpioid dependence severitySmoking quantitySmoking status
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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