rs12453
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
dementia
“A genome-wide association meta-analysis of all-cause and vascular dementia.” Alzheimer's & Dementia : the Journal of the Alzheimer's Association 20(9):5973-5995 (2024)
Allele C
OR 0.09
p 1.0e-16
N 510,615
Meta-analysisLarge GWAS
European
Alzheimer disease, dementia, family history of Alzheimer’s disease
Zhang YR et al. “Whole exome sequencing analyses identified novel genes for Alzheimer's disease and related dementia.” Alzheimer's & Dementia : the Journal of the Alzheimer's Association 20(10):7062-7078 (2024)
Allele C
OR 0.96
p 3.0e-10
N 349,990
Large GWAS
European
Lewy body dementia
Guo P et al. “Pinpointing novel risk loci for Lewy body dementia and the shared genetic etiology with Alzheimer's disease and Parkinson's disease: a large-scale multi-trait association analysis.” Bmc Medicine 20(1):214 (2022)
Allele C
OR 5.74
p 1.0e-8
N 6,618
Large GWAS
European
neutrophil count
Chen MH et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182(5):1198-1213.e14 (2020)
Allele C
OR —
p 4.0e-12
N 627,215
Large GWAS
multi-ancestry
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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