rs12552
This is a 3 prime utr variant variant in the OLFM4 gene.
▶GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
bipolar disorder, major depressive disorder
Coleman JRI et al. “The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls.” Biological Psychiatry 88(2):169-184 (2020)
Allele A
OR 1.04
p 1.0e-23
N 625,026
Large GWAS
European
major depressive disorder
Wray NR et al. “Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.” Nature Genetics 50(5):668-681 (2018)
Allele A
OR 1.04
p 6.0e-19
N 480,359
Large GWAS
European
Nagel M et al. “Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.” Nature Genetics 50(7):920-927 (2018)
Allele A
OR 6.37
p 2.0e-10
N 688,809
Meta-analysisLarge GWAS
European
Hyde CL et al. “Identification of 15 genetic loci associated with risk of major depression in individuals of European descent.” Nature Genetics 48(9):1031-6 (2016)
Allele A
OR 0.04
p 8.0e-9
N 326,113
Large GWAS
European
self reported educational attainment
Lee JJ et al. “Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.” Nature Genetics 50(8):1112-1121 (2018)
Allele A
OR 0.01
p 5.0e-9
N 1,131,881
Large GWAS
European
intelligence
Hill WD et al. “A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence.” Molecular Psychiatry 24(2):169-181 (2019)
Allele A
OR 0.02
p 3.0e-8
N 248,482
Large GWAS
European
autism spectrum disorder, major depressive disorder
Grove J et al. “Identification of common genetic risk variants for autism spectrum disorder.” Nature Genetics 51(3):431-444 (2019)
Allele A
OR 0.05
p 4.0e-8
N 470,365
Large GWAS
European
insomnia
Watanabe K et al. “Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways.” Nature Genetics 54(8):1125-1132 (2022)
Allele A
OR 0.01
p 1.0e-19
N 1,216,033
Meta-analysisLarge GWAS
European
About OLFM4
This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. [provided by RefSeq, Mar 2011]
View all OLFM4 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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