rs12593558
This variant is located in the CD276 gene.
▶Research that mentions this SNP (1)
▶A risk assessment model of acute liver allograft rejection by genetic polymorphism of CD276AssociationN=388Xiaobo Yu et al.(2019)· Molecular Genetics & Genomic Medicine
A case-control study of 388 liver transplant recipients identified genetic polymorphisms in CD276 and TREML2 associated with acute allograft rejection. SNPs rs2127015 (CD276), rs6915083 and rs7754593 (TREML2) were significantly associated with acute rejection, with rs2127015 T-allele carriers showing higher CD276 expression. A risk assessment model combining rs2127015 genotype and HBV infection status achieved 69.8% sensitivity and 63.4% AUC, stratifying recipients into low-, medium-, and high-risk groups with rejection incidence rates of 4.3-20.8%.
About CD276
The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
View all CD276 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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