CD276
CD276 molecule
Summary
The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Known Variants59 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs8038465 | 15:73,978,337 | C/T | intron variant | — |
| rs67257650 | 15:73,979,507 | C/G | — | — |
| rs2127015 | 15:73,985,223 | T/C | intron variant | — |
| rs12594627 | 15:73,986,264 | G/C | — | — |
| rs11072431 | 15:73,987,642 | T/A | intron variant | — |
| rs11852484 | 15:73,988,652 | G/A | regulatory region variant | — |
| rs12593558 | 15:73,993,571 | T/A | — | — |
| rs769865072 | 15:73,994,598 | G/T | — | uncertain significance |
| rs766904389 | 15:73,994,607 | G/A | — | uncertain significance |
| rs1022188310 | 15:73,994,616 | C/T | — | uncertain significance |
| rs370507291 | 15:73,994,668 | C/T | — | uncertain significance |
| rs2542684847 | 15:73,994,682 | C/T | — | uncertain significance |
| rs374351828 | 15:73,994,703 | C/G | — | uncertain significance |
| rs141119771 | 15:73,994,850 | G/A | — | uncertain significance |
| rs770650860 | 15:73,994,854 | G/A | — | likely benign |
| rs200105637 | 15:73,994,865 | G/A | — | uncertain significance |
| rs2542686702 | 15:73,994,882 | C/G | — | uncertain significance |
| rs374277885 | 15:73,994,886 | G/A | — | uncertain significance |
| rs780694082 | 15:73,994,896 | G/A | — | uncertain significance |
| rs538781194 | 15:73,994,916 | G/A | — | uncertain significance |
| rs1309632734 | 15:73,994,917 | T/C | — | uncertain significance |
| rs763479996 | 15:73,995,203 | G/A | — | uncertain significance |
| rs199719127 | 15:73,995,238 | C/A | — | uncertain significance |
| rs138502254 | 15:73,995,239 | A/C | — | uncertain significance |
| rs752346401 | 15:73,995,349 | A/G | — | uncertain significance |
| rs199765601 | 15:73,995,370 | G/A | — | uncertain significance |
| rs577717498 | 15:73,995,384 | T/G | — | uncertain significance |
| rs772535341 | 15:73,995,409 | C/T | — | uncertain significance |
| rs1596015082 | 15:73,995,990 | C/T | — | likely benign |
| rs10083677 | 15:73,995,993 | C/T | — | benign |
| rs760558160 | 15:73,996,078 | C/T | — | uncertain significance |
| rs776686900 | 15:73,996,083 | G/A | — | uncertain significance |
| rs772981824 | 15:73,996,168 | G/A | — | uncertain significance |
| rs769691860 | 15:73,996,254 | G/A | — | uncertain significance |
| rs762931731 | 15:73,996,258 | G/A | — | uncertain significance |
| rs2542697886 | 15:73,996,272 | G/A | — | uncertain significance |
| rs754336923 | 15:73,996,299 | C/T | — | uncertain significance |
| rs780867163 | 15:73,996,314 | G/A | — | uncertain significance |
| rs2542698289 | 15:73,996,318 | C/T | — | uncertain significance |
| rs146707793 | 15:73,996,338 | G/A | missense variant | — |
| rs140663039 | 15:73,996,537 | A/C | — | uncertain significance |
| rs754785892 | 15:73,996,564 | C/T | — | uncertain significance |
| rs778780413 | 15:73,996,565 | G/A | — | uncertain significance |
| rs374890808 | 15:73,996,598 | G/T | — | uncertain significance |
| rs751682061 | 15:73,996,629 | C/A | — | likely benign |
| rs372124791 | 15:73,996,676 | C/T | — | uncertain significance |
| rs150877011 | 15:73,996,701 | G/A | — | benign |
| rs147409005 | 15:73,996,717 | G/A | — | uncertain significance |
| rs62641691 | 15:73,996,729 | G/A | missense variant | — |
| rs767540312 | 15:73,996,762 | G/C | — | uncertain significance |
| rs374412194 | 15:73,996,772 | C/G | — | uncertain significance |
| rs775147523 | 15:73,996,790 | C/T | — | uncertain significance |
| rs761709030 | 15:73,996,796 | G/C | — | uncertain significance |
| rs7176654 | 15:73,999,006 | A/G | intron variant | — |
| rs200206394 | 15:74,000,715 | G/A | — | uncertain significance |
| rs556281946 | 15:74,000,799 | G/C | — | uncertain significance |
| rs11574495 | 15:74,003,936 | G/C | — | — |
| rs3816661 | 15:74,005,600 | C/T | 3 prime UTR variant | — |
| rs561502193 | 15:74,006,264 | C/G | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.