rs12829722

This is a downstream gene variant variant in the UNC119B gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

metabolite measurement

Schlosser P et al. “Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine.” Nature Genetics 55(6):995-1008 (2023)

Allele T

OR 0.19

p 6.0e-31

N 4,954

Large GWAS

European

methylsuccinoylcarnitine measurement

Feofanova EV et al. “Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations.” Nature Communications 14(1):3111 (2023)

Allele T

OR 0.34

p 5.0e-25

N 2,411

Large GWAS

multi-ancestry

substance-related disorder

Lai D et al. “Genome-wide meta-analyses of cross substance use disorders in diverse populations.” Molecular Psychiatry 31(3):1619-1633 (2026)

Allele T

OR 5.91

p 3.0e-9

N 1,699,295

Large GWAS

multi-ancestry

About UNC119B

Enables lipid binding activity. Involved in cilium assembly and lipoprotein transport. Located in ciliary transition zone. [provided by Alliance of Genome Resources, Jul 2025]

View all UNC119B variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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