rs12840919

This is a intron variant variant in the FRMPD4 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

schizophrenia

Trubetskoy V et al. “Mapping genomic loci implicates genes and synaptic biology in schizophrenia.” Nature 604(7906):502-508 (2022)

Allele G

OR 0.95

p 3.0e-8

N 175,799

Large GWAS

multi-ancestry

About FRMPD4

This gene encodes a multi-domain (WW, PDZ, FERM) containing protein. Through its interaction with other proteins (such as PSD-95), it functions as a positive regulator of dendritic spine morphogenesis and density, and is required for the maintenance of excitatory synaptic transmission. [provided by RefSeq, Jan 2010]

View all FRMPD4 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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