rs12897751

This is a downstream gene variant variant.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

LDL particle size

Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele C
OR 0.07
p 3.0e-30
N 136,016
Large GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis
AssociationN=638Dorothea Buck et al.(2013)· Annals of Neurology

A genome-wide association study identified five SNPs in the immunoglobulin heavy chain locus (IGHC) on chromosome 14q32.33 associated with the IgG index, a measure of intrathecal IgG synthesis in multiple sclerosis patients. The strongest association was rs10136766 (p = 7.5 × 10⁻¹⁶), which explained 8.9% of variance and was associated with the GM21* haplotype. These SNPs showed no association with MS susceptibility itself.

Traits studied:IgG indexIntrathecal IgG synthesisMultiple sclerosis
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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