rs12906962

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GWAS Catalog Trait Associations (8)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

diastolic blood pressure

Keaton JM et al. “Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.” Nature Genetics 56(5):778-791 (2024)

Allele C

OR 0.21

p 1.0e-36

N 1,028,980

Large GWAS

multi-ancestry

Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)

Allele C

OR 0.02

p 2.0e-33

N 1,212,859

Large GWAS

European

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)

Allele C

OR 0.02

p 5.0e-27

N 928,679

Large GWAS

multi-ancestry

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele C

OR 0.02

p 2.0e-17

N 485,677

Large GWAS

multi-ancestry

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele C

OR 0.02

p 6.0e-21

N 394,642

Large GWAS

European

Hoffmann TJ et al. “Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.” Nature Genetics 49(1):54-64 (2017)

Allele C

OR 0.16

p 1.0e-10

N 321,262

Large GWAS

multi-ancestry

Warren HR et al. “Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.” Nature Genetics 49(3):403-415 (2017)

Allele C

OR 0.22

p 6.0e-14

N 140,886

Large GWAS

European

heart rate

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele C

OR 0.03

p 3.0e-33

N 394,642

Large GWAS

European

systolic blood pressure

Allele C

OR 0.23

p 5.0e-19

N 1,028,980

Large GWAS

multi-ancestry

Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)

Allele C

OR 0.01

p 2.0e-16

N 1,212,859

Large GWAS

European

Allele C

OR 0.01

p 9.0e-15

N 928,679

Large GWAS

multi-ancestry

Giri A et al. “Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.” Nature Genetics 51(1):51-62 (2019)

Allele C

OR 0.23

p 5.0e-11

N 459,777

Large GWAS

multi-ancestry

heart rate response to exercise

Verweij N et al. “Genetic study links components of the autonomous nervous system to heart-rate profile during exercise.” Nature Communications 9(1):898 (2018)

Allele T

OR 0.05

p 3.0e-14

N 58,818

Large GWAS

multi-ancestry

Ramírez J et al. “Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system.” Nature Communications 9(1):1947 (2018)

Allele T

OR 0.47

p 4.0e-13

N 67,257

Large GWAS

European

mean arterial pressure

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele C

OR 0.02

p 4.0e-13

N 506,365

Large GWAS

multi-ancestry

Beta blocking agent use measurement

Wu Y et al. “Genome-wide association study of medication-use and associated disease in the UK Biobank.” Nature Communications 10(1):1891 (2019)

Allele C

OR 0.05

p 1.0e-9

N 224,024

Major Consortium StudyLarge GWAS

European

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele C

OR 0.04

p 2.0e-9

N 402,750

Large GWAS

multi-ancestry

heart rate response to recovery post exercise

Verweij N et al. “Genetic study links components of the autonomous nervous system to heart-rate profile during exercise.” Nature Communications 9(1):898 (2018)

Allele T

OR 0.04

p 3.0e-9

N 58,818

Large GWAS

multi-ancestry

Ramírez J et al. “Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system.” Nature Communications 9(1):1947 (2018)

Allele T

OR 0.34

p 5.0e-9

N 67,257

Large GWAS

European

Calcium channel blocker use measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele C

OR 0.04

p 2.0e-8

N 383,104

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

rs12906962

GWAS Catalog Trait Associations (8)

diastolic blood pressure

heart rate

systolic blood pressure

heart rate response to exercise

mean arterial pressure

Beta blocking agent use measurement

heart rate response to recovery post exercise

Calcium channel blocker use measurement

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