rs12938775

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GWAS Catalog Trait Associations (7)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

neuroticism measurement

Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)
Allele A
OR 6.84
p 8.0e-12
N 380,506
Large GWAS
European
Nagel M et al. “Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.” Nature Genetics 50(7):920-927 (2018)
Allele A
OR 6.75
p 1.0e-11
N 449,484
Meta-analysisLarge GWAS
European
Luciano M et al. “Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism.” Nature Genetics 50(1):6-11 (2018)
Allele A
OR 6.49
p 8.0e-11
N 329,821
Large GWAS
European
Okbay A et al. “Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.” Nature Genetics 48(6):624-33 (2016)
Allele A
OR 0.02
p 9.0e-9
N 170,911
Large GWAS
European

anxiety measurement

Thorp JG et al. “Symptom-level modelling unravels the shared genetic architecture of anxiety and depression.” Nature Human Behaviour 5(10):1432-1442 (2021)
Allele G
OR 0.02
p 2.0e-11
N 136,957
Large GWAS
European

neurotic disorder

Cai N et al. “Minimal phenotyping yields genome-wide association signals of low specificity for major depression.” Nature Genetics 52(4):437-447 (2020)
Allele G
OR 0.01
p 2.0e-9
N 274,107
Large GWAS
European

insomnia

Watanabe K et al. “Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways.” Nature Genetics 54(8):1125-1132 (2022)
Allele A
OR 0.01
p 1.0e-8
N 2,365,010
Meta-analysisLarge GWAS
European

body height

Yengo L et al. “A saturated map of common genetic variants associated with human height.” Nature 610(7933):704-712 (2022)
Allele G
OR 0.02
p 1.0e-8
N 472,730
Large GWAS
East Asian

cortical thickness

Zhukovsky P et al. “Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression.” Nature Communications 15(1):5207 (2024)
Allele A
OR —
p 8.0e-10
N 34,571
Large GWAS
European
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Research that mentions this SNP (1)

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Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging
AssociationN=648Kristin K. Nicodemus et al.(2010)· Human Genetics

This case-control association study identified statistical epistasis between SNPs in DISC1, CIT, and NDEL1 genes impacting schizophrenia risk (N=289 cases, 359 controls). Four significant two-SNP interactions were detected: NDEL1 rs4791707-CIT rs10744743 (OR=4.44, p=0.00013, Bonferroni-corrected); DISC1 rs1411771-CIT rs10744743 (OR=3.07, p=0.007); CIT rs3847960-CIT rs203332 (OR=2.90, p=0.003); CIT rs3847960-CIT rs440299 (OR=2.16, p=0.038). Three of four interactions were biologically validated via fMRI in an independent healthy control sample (N=217-260), showing that risk-associated genotype combinations predicted prefrontal cortical inefficiency during working memory tasks.

Traits studied:PsychosisSchizoaffective disorderSchizophreniaSchizophreniform disorder
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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