rs12943962
This is a coding sequence variant variant in the RNF227 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
prostate carcinoma
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.15
p 3.0e-19
N 573,692
Major Consortium StudyLarge GWAS
multi-ancestry
substance-related disorder
Lai D et al. “Genome-wide meta-analyses of cross substance use disorders in diverse populations.” Molecular Psychiatry 31(3):1619-1633 (2026)
Allele T
OR 5.55
p 3.0e-8
N 1,699,295
Large GWAS
multi-ancestry
About RNF227
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. [provided by Alliance of Genome Resources, Jul 2025]
View all RNF227 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…