rs13112725

This is a intron variant variant.

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GWAS Catalog Trait Associations (8)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

systolic blood pressure

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)

Allele C

OR 0.02

p 2.0e-30

N 928,679

Large GWAS

multi-ancestry

Hoffmann TJ et al. “Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.” Nature Genetics 49(1):54-64 (2017)

Allele C

OR 0.30

p 2.0e-11

N 321,262

Large GWAS

multi-ancestry

Wain LV et al. “Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.” Hypertension (dallas, Tex. : 1979) 70(3):e4-e19 (2017)

Allele C

OR 0.41

p 3.0e-16

N 150,134

Large GWAS

multi-ancestry

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele C

OR 0.02

p 3.0e-8

N 145,505

Large GWAS

East Asian

Warren HR et al. “Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.” Nature Genetics 49(3):403-415 (2017)

Allele C

OR 0.43

p 2.0e-14

N 140,882

Large GWAS

European

Takeuchi F et al. “Interethnic analyses of blood pressure loci in populations of East Asian and European descent.” Nature Communications 9(1):5052 (2018)

Allele C

OR 0.38

p 3.0e-8

N 130,777

Large GWAS

multi-ancestry

diastolic blood pressure

Plotnikov D et al. “High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study.” Investigative Ophthalmology & Visual Science 63(6):29 (2022)

Allele C

OR 0.24

p 3.0e-22

N 526,001

Large GWAS

European

Allele C

OR 0.02

p 5.0e-21

N 928,679

Large GWAS

multi-ancestry

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele C

OR 0.01

p 1.0e-9

N 485,677

Large GWAS

multi-ancestry

Hoffmann TJ et al. “Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.” Nature Genetics 49(1):54-64 (2017)

Allele C

OR 0.15

p 3.0e-8

N 321,262

Large GWAS

multi-ancestry

mean arterial pressure

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele C

OR 0.02

p 2.0e-14

N 506,365

Large GWAS

multi-ancestry

Agents acting on the renin-angiotensin system use measurement

Wu Y et al. “Genome-wide association study of medication-use and associated disease in the UK Biobank.” Nature Communications 10(1):1891 (2019)

Allele G

OR 0.05

p 5.0e-12

N 237,530

Major Consortium StudyLarge GWAS

European

pulse pressure measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele C

OR 0.01

p 5.0e-12

N 506,308

Large GWAS

multi-ancestry

atrial fibrillation

Yuan S et al. “Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation.” Nature Communications 16(1):6426 (2025)

Allele C

OR 0.02

p 7.0e-10

N 2,584,013

Large GWAS

multi-ancestry

Diuretic use measurement

Wu Y et al. “Genome-wide association study of medication-use and associated disease in the UK Biobank.” Nature Communications 10(1):1891 (2019)

Allele G

OR 0.06

p 8.0e-10

N 229,086

Major Consortium StudyLarge GWAS

European

cup-to-disc ratio measurement

Alipanahi B et al. “Large-scale machine-learning-based phenotyping significantly improves genomic discovery for optic nerve head morphology.” American Journal of Human Genetics 108(7):1217-1230 (2021)

Allele G

OR 0.03

p 3.0e-8

N 89,579

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

rs13112725

GWAS Catalog Trait Associations (8)

systolic blood pressure

diastolic blood pressure

mean arterial pressure

Agents acting on the renin-angiotensin system use measurement

pulse pressure measurement

atrial fibrillation

Diuretic use measurement

cup-to-disc ratio measurement

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