rs13181561

This is a downstream gene variant variant in the SMIM33 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

C-X-C motif chemokine 11 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele A

OR 0.05

p 1.0e-16

N 47,745

Large GWAS

European

response to vaccine, cytokine measurement

Kennedy RB et al. “Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients” Human Genetics (2012)

Allele G

OR —

p 3.0e-14

N 711

Small GWAS

multi-ancestry

hypothyroidism

White SL et al. “Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.” Nature Genetics 58(2):307-316 (2026)

Allele A

OR 0.03

p 1.0e-11

N 1,786,062

Large GWAS

European

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Research that mentions this SNP (1)

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Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients

AssociationN=1,000Kennedy RB et al.(2012)· Human Genetics

Genome-wide association study identifying SNPs associated with cytokine responses to vaccinia virus in 1,000 smallpox vaccine recipients. Multiple SNPs achieved genome-wide significance (p<5×10⁻⁷) for Th1 cytokines (IL-2, TNFα, IL-12p40) and inflammatory cytokines (IL-1β, IFNα, IL-6). Notable findings include rs16948200 in NGFR (12-fold difference in IL-2 secretion between genotypes), rs4251424 in IRAK4 (associated with TNFα), and rs2255327 in BLK (2-fold higher IL-6 in heterozygotes).

Traits studied:Cytokine response to vaccinia virusIFN alpha secretionIFN beta secretionIL-1 beta secretionIL-10 secretionIL-12p40 secretionIL-12p70 secretionIL-18 secretionIL-2 secretionIL-4 secretionIL-6 secretionInflammatory responseTNF alpha secretionTh1 immune responseTh2 immune response

PubMed DOI Metascience Observatory

About SMIM33

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]