rs13210554
This is a upstream gene variant variant in the PLA2G7 gene.
▶Research that mentions this SNP (1)
▶Associations of PLA2G7 gene polymorphisms with plasma lipoprotein-associated phospholipase A2 activity and coronary heart disease in a Chinese Han population: the Beijing atherosclerosis studyAssociationN=1,774Liping Hou et al.(2009)· Human Genetics
This case-control study of 827 Chinese Han coronary heart disease (CHD) patients and 947 controls examined associations of seven PLA2G7 gene polymorphisms with Lp-PLA2 activity and CHD/MI risk. Lp-PLA2 activity was significantly elevated in CHD (233.42±57.66) and MI (234.27±59.51) patients versus controls (211.47±58.61), with OR=1.27 (95% CI 1.07-1.50) per 1 SD increase after adjustment. V279F and I198T variants significantly reduced Lp-PLA2 activity but were not associated with increased CHD risk. The rs13210554 T allele showed independent association with MI (adjusted OR reported in univariate analysis), with haplotype Hap3 carrying this allele showing OR=1.43 (95% CI 1.03-1.98) for MI.
About PLA2G7
The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2009]
View all PLA2G7 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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