PLA2G7

phospholipase A2 group VII

Summary

The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2009]

Known Variants55 total

rsidPosition (GRCh37)AllelesClassClinVar
rs2012194736:46,672,339G/Alikely benign
rs1402683116:46,672,346T/Cuncertain significance
rs1378831696:46,672,394T/Cuncertain significance
rs10519316:46,672,943A/Gmissense variantbenign
rs2020734186:46,673,012T/Cuncertain significance
rs2000151606:46,673,013C/Auncertain significance
rs3736786556:46,673,055C/Tlikely benign
rs77569356:46,675,025C/Adownstream gene variant
rs17648939786:46,675,893C/Auncertain significance
rs7578718766:46,675,900T/Cuncertain significance
rs768634416:46,677,098C/Amissense variantpathogenic
rs25326880896:46,677,136T/Cuncertain significance
rs17649363816:46,677,139T/Cuncertain significance
rs7702006306:46,677,146C/Tuncertain significance
rs1440678696:46,677,170A/Gintron variant
rs25326910746:46,678,266A/Guncertain significance
rs2003517976:46,678,285C/Tlikely benign
rs15825661666:46,678,363A/Glikely benign
rs2003387806:46,678,373C/Tuncertain significance
rs2016155396:46,678,382G/Cuncertain significance
rs1406954656:46,678,391C/Tlikely benign
rs2000576496:46,678,392G/Auncertain significance
rs2018998666:46,679,232C/Tsplice region variantpathogenic
rs1393846066:46,679,262C/Tuncertain significance
rs1500390376:46,679,283A/Guncertain significance
rs7643178766:46,679,301C/Tuncertain significance
rs18050186:46,679,303A/Gmissense variantbenign
rs454546956:46,679,323C/Gbenign
rs7766751076:46,680,024A/Guncertain significance
rs5481824446:46,680,033C/Tuncertain significance
rs1837021316:46,680,070G/Tlikely benign
rs13629316:46,682,079A/Cintron variant
rs14203681136:46,682,196C/Tlikely pathogenic
rs17651326196:46,682,201A/Cuncertain significance
rs3708310216:46,682,233G/Auncertain significance
rs7760371986:46,682,234G/Auncertain significance
rs2002764216:46,682,245C/Tuncertain significance
rs2021504636:46,682,257G/Auncertain significance
rs2004541216:46,682,265C/Tuncertain significance
rs7638825436:46,684,127G/Alikely benign
rs9366413156:46,684,140G/Tlikely benign
rs1430122496:46,684,168A/Guncertain significance
rs18050176:46,684,222C/Tmissense variantbenign
rs3682344076:46,684,246T/Cuncertain significance
rs10057518716:46,684,721G/Alikely benign
rs7677245466:46,684,750C/Tuncertain significance
rs1453154336:46,684,792A/Tlikely benign
rs1485970636:46,684,817T/Cuncertain significance
rs5744763646:46,685,732C/T
rs1429748986:46,690,518A/Glikely pathogenic
rs7718357106:46,690,534T/Cuncertain significance
rs1996836086:46,690,590G/Alikely benign
rs3756654506:46,690,625C/Tuncertain significance
rs93952086:46,703,319G/Cregulatory region variant
rs132105546:46,704,339C/Tupstream gene variant

Gene information from NCBI Gene. Variant classifications from ClinVar.