rs1805017
This is a variant in the PLA2G7 gene that changes a arginine to an histidine.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
lipoprotein-associated phospholipase A(2) measurement
Grallert H et al. “Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies.” European Heart Journal 33(2):238-51 (2012)
Allele T
OR 0.04
p 2.0e-23
N 13,664
Meta-analysisLarge GWAS
European
Suchindran S et al. “Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study.” Plos Genetics 6(4):e1000928 (2010)
Allele T
OR 11.10
p 6.0e-14
N 6,668
CohortLarge GWAS
European
▶ClinVar annotation
About PLA2G7
The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2009]
View all PLA2G7 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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